Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Light-controlled modulation of gene expression by chemical optoepigenetic probes.

Reis, Surya A; Ghosh, Balaram; Hendricks, J Adam; Szantai-Kis, D Miklos; Törk, Lisa; Ross, Kenneth N; Lamb, Justin; Read-Button, Willis; Zheng, Baixue; Wang, Hongtao; Salthouse, Christopher; Haggarty, Stephen J; Mazitschek, Ralph.

Nat Chem Biol ; 12(5): 317-23, 2016 May.

Artigo em Inglês | MEDLINE | ID: mdl-26974814

2.

Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.

Ghosh, Balaram; Zhao, Wen-Ning; Reis, Surya A; Patnaik, Debasis; Fass, Daniel M; Tsai, Li-Huei; Mazitschek, Ralph; Haggarty, Stephen J.

Bioorg Med Chem Lett ; 26(4): 1265-1271, 2016 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-26804233

3.

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.

Wagner, Florence F; Weïwer, Michel; Steinbacher, Stefan; Schomburg, Adrian; Reinemer, Peter; Gale, Jennifer P; Campbell, Arthur J; Fisher, Stewart L; Zhao, Wen-Ning; Reis, Surya A; Hennig, Krista M; Thomas, Méryl; Müller, Peter; Jefson, Martin R; Fass, Daniel M; Haggarty, Stephen J; Zhang, Yan-Ling; Holson, Edward B.

Bioorg Med Chem ; 24(18): 4008-4015, 2016 09 15.

Artigo em Inglês | MEDLINE | ID: mdl-27377864

4.

Monoalkoxy BODIPYs--a fluorophore class for bioimaging.

Courtis, Alexandra M; Santos, Sofia A; Guan, Yinghua; Hendricks, J Adam; Ghosh, Balaram; Szantai-Kis, D Miklos; Reis, Surya A; Shah, Jagesh V; Mazitschek, Ralph.

Bioconjug Chem ; 25(6): 1043-51, 2014 Jun 18.

Artigo em Inglês | MEDLINE | ID: mdl-24797834

5.

Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.

Rosenthal, Zachary C; Fass, Daniel M; Payne, N Connor; She, Angela; Patnaik, Debasis; Hennig, Krista M; Tesla, Rachel; Werthmann, Gordon C; Guhl, Charlotte; Reis, Surya A; Wang, Xiaoyu; Chen, Yueting; Placzek, Michael; Williams, Noelle S; Hooker, Jacob; Herz, Joachim; Mazitschek, Ralph; Haggarty, Stephen J.

Sci Rep ; 14(1): 9064, 2024 04 20.

Artigo em Inglês | MEDLINE | ID: mdl-38643236

6.

Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.

Reis, Surya A; Thompson, Morgan N; Lee, Jong-Min; Fossale, Elisa; Kim, Hyung-Hwan; Liao, James K; Moskowitz, Michael A; Shaw, Stanley Y; Dong, Linda; Haggarty, Stephen J; MacDonald, Marcy E; Seong, Ihn Sik.

Hum Mol Genet ; 20(12): 2344-55, 2011 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-21447599

7.

High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy.

Cheng, Chialin; Reis, Surya A; Adams, Emily T; Fass, Daniel M; Angus, Steven P; Stuhlmiller, Timothy J; Richardson, Jared; Olafson, Hailey; Wang, Eric T; Patnaik, Debasis; Beauchamp, Roberta L; Feldman, Danielle A; Silva, M Catarina; Sur, Mriganka; Johnson, Gary L; Ramesh, Vijaya; Miller, Bruce L; Temple, Sally; Kosik, Kenneth S; Dickerson, Bradford C; Haggarty, Stephen J.

Sci Rep ; 11(1): 17029, 2021 08 23.

Artigo em Inglês | MEDLINE | ID: mdl-34426604

8.

An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.

Marcaurelle, Lisa A; Comer, Eamon; Dandapani, Sivaraman; Duvall, Jeremy R; Gerard, Baudouin; Kesavan, Sarathy; Lee, Maurice D; Liu, Haibo; Lowe, Jason T; Marie, Jean-Charles; Mulrooney, Carol A; Pandya, Bhaumik A; Rowley, Ann; Ryba, Troy D; Suh, Byung-Chul; Wei, Jingqiang; Young, Damian W; Akella, Lakshmi B; Ross, Nathan T; Zhang, Yan-Ling; Fass, Daniel M; Reis, Surya A; Zhao, Wen-Ning; Haggarty, Stephen J; Palmer, Michelle; Foley, Michael A.

J Am Chem Soc ; 132(47): 16962-76, 2010 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-21067169

9.

TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling.

Martin, Pauline; Wagh, Vilas; Reis, Surya A; Erdin, Serkan; Beauchamp, Roberta L; Shaikh, Ghalib; Talkowski, Michael; Thiele, Elizabeth; Sheridan, Steven D; Haggarty, Stephen J; Ramesh, Vijaya.

Mol Autism ; 11(1): 2, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-31921404

10.

An Autophagy Modifier Screen Identifies Small Molecules Capable of Reducing Autophagosome Accumulation in a Model of CLN3-Mediated Neurodegeneration.

Petcherski, Anton; Chandrachud, Uma; Butz, Elisabeth S; Klein, Madeleine C; Zhao, Wen-Ning; Reis, Surya A; Haggarty, Stephen J; Ruonala, Mika O; Cotman, Susan L.

Cells ; 8(12)2019 11 27.

Artigo em Inglês | MEDLINE | ID: mdl-31783699

11.

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.

Hernandez, Israel; Luna, Gabriel; Rauch, Jennifer N; Reis, Surya A; Giroux, Michel; Karch, Celeste M; Boctor, Daniel; Sibih, Youssef E; Storm, Nadia J; Diaz, Antonio; Kaushik, Susmita; Zekanowski, Cezary; Kang, Alexander A; Hinman, Cassidy R; Cerovac, Vesna; Guzman, Elmer; Zhou, Honjun; Haggarty, Stephen J; Goate, Alison M; Fisher, Steven K; Cuervo, Ana M; Kosik, Kenneth S.

Sci Transl Med ; 11(485)2019 03 27.

Artigo em Inglês | MEDLINE | ID: mdl-30918111

12.

Structural Basis for Achieving GSK-3ß Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery.

Bernard-Gauthier, Vadim; Mossine, Andrew V; Knight, Ashley; Patnaik, Debasis; Zhao, Wen-Ning; Cheng, Chialin; Krishnan, Hema S; Xuan, Lucius L; Chindavong, Peter S; Reis, Surya A; Chen, Jinshan Michael; Shao, Xia; Stauff, Jenelle; Arteaga, Janna; Sherman, Phillip; Salem, Nicolas; Bonsall, David; Amaral, Brenda; Varlow, Cassis; Wells, Lisa; Martarello, Laurent; Patel, Shil; Liang, Steven H; Kurumbail, Ravi G; Haggarty, Stephen J; Scott, Peter J H; Vasdev, Neil.

J Med Chem ; 62(21): 9600-9617, 2019 11 14.

Artigo em Inglês | MEDLINE | ID: mdl-31535859

13.

Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling.

Garza, Jacob C; Qi, Xiaoli; Gjeluci, Klaudio; Leussis, Melanie P; Basu, Himanish; Reis, Surya A; Zhao, Wen Ning; Piguel, Nicolas H; Penzes, Peter; Haggarty, Stephen J; Martens, Gerard J; Poelmans, Geert; Petryshen, Tracey L.

Transl Psychiatry ; 8(1): 135, 2018 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-30046097

14.

Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability.

Lalonde, Jasmin; Reis, Surya A; Sivakumaran, Sudhir; Holland, Carl S; Wesseling, Hendrik; Sauld, John F; Alural, Begum; Zhao, Wen-Ning; Steen, Judith A; Haggarty, Stephen J.

Nat Commun ; 8(1): 1659, 2017 11 21.

Artigo em Inglês | MEDLINE | ID: mdl-29162813

15.

Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.

She, Angela; Kurtser, Iren; Reis, Surya A; Hennig, Krista; Lai, Jenny; Lang, Audrey; Zhao, Wen-Ning; Mazitschek, Ralph; Dickerson, Bradford C; Herz, Joachim; Haggarty, Stephen J.

Cell Chem Biol ; 24(7): 892-906.e5, 2017 Jul 20.

Artigo em Inglês | MEDLINE | ID: mdl-28712747

16.

Prospects of TAT-mediated protein therapy for fragile X syndrome.

Reis, Surya A; Willemsen, Rob; van Unen, Leontine; Hoogeveen, Andre T; Oostra, Ben A.

J Mol Histol ; 35(4): 389-95, 2004 May.

Artigo em Inglês | MEDLINE | ID: mdl-15503812

17.

Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.

Fass, Daniel M; Reis, Surya A; Ghosh, Balaram; Hennig, Krista M; Joseph, Nadine F; Zhao, Wen-Ning; Nieland, Thomas J F; Guan, Ji-Song; Kuhnle, Chelsea E Groves; Tang, Weiping; Barker, Douglas D; Mazitschek, Ralph; Schreiber, Stuart L; Tsai, Li-Huei; Haggarty, Stephen J.

Neuropharmacology ; 64: 81-96, 2013 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-22771460

18.

Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome.

Sheridan, Steven D; Theriault, Kraig M; Reis, Surya A; Zhou, Fen; Madison, Jon M; Daheron, Laurence; Loring, Jeanne F; Haggarty, Stephen J.

PLoS One ; 6(10): e26203, 2011.

Artigo em Inglês | MEDLINE | ID: mdl-22022567

19.

Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.

Fass, Daniel M; Shah, Rishita; Ghosh, Balaram; Hennig, Krista; Norton, Stephanie; Zhao, Wen-Ning; Reis, Surya A; Klein, Peter S; Mazitschek, Ralph; Maglathlin, Rebecca L; Lewis, Timothy A; Haggarty, Stephen J.

ACS Med Chem Lett ; 2(1): 39-42, 2010 Oct 08.

Artigo em Inglês | MEDLINE | ID: mdl-21874153

20.

Isolation of mouse neuritic mRNAs.

Reis, Surya A; Oostra, Ben A; Willemsen, Rob.

J Mol Histol ; 37(1-2): 79-86, 2006 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-16821094

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